A consistent inability to sustain an erection sufficient for sexual intercourse. Also commonly known as impotence. Medically, the term erectile dysfunction is used to differentiate impotence from other problems that interfere with sexual intercourse The following drugs and medications are in some way related to, or used in the treatment of Impotence. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
Viagra is giving older men a new sex life, but many wives are upset about it. According to a $600,000 study paid for by the Health Research Council of New Zealand, plenty of women are blaming health care providers for giving their husbands Viagra without considering its effects on them. These women believe men's clinics use Viagra as a quick fix for men instead of assisting couples with other issues in their relationship or just accepting that older people do not require sex as often as younger people. The study was conducted on the basis of direct interviews with 27 women with an average age of 53, and 33 men who were interested in being a part of the study. Officially, more than 15 million people around the world have taken Viagra since its inception in 1998. Despite being a costly affair, people are still fond of this drug. Viagra’s price is $100 for a packet of four pills; each pill can have an effect for up to 12 hours. About a quarter of the women came forward for the research because they were interested in discussing about the detrimental effects of Viagra. The other three quarters of the women came into the study because they were not feeling at ease with all the sex they were compelled to perform after their husbands opted for Viagra. Women told the researchers that they feel unnecessary pressure to have sex at night as well as the next morning so the husband could double their pleasure. A few older women experienced pain during sex due to post menopausal vaginal dryness even when they were using lubricants during sex. The irony is that most of the health providers just treat this as a men’s problem rather than a couple’s problem. It is mandatory that how woman feels should be taken into account. Doctors are of the opinion that when male patients asked for prescription of Viagra, they cannot force them to talk to their partners first. According to doctors, interaction between the partners is extremely crucial in this matter but, though they encourage it among male patients, to implement it rests solely in the hands of male patients. Interestingly, those women who are not interested in having sex more frequently risked being labelled dysfunctional themselves causing some pressure on them to have some medical evaluation.
Generic Viagra is a drug used for erectile dysfunctions, or male impotence, and it represents the name for a substance known as sildenafil citrate. The substance is the same, while the market name of the drug may vary and so may its price. Generic versions for many types of drugs have been around for quite some time, but Generic Viagra is a fairly new drug on the market, and it gives men a chance at treating their erectile dysfunctions in an affordable way. Generic Viagra can be expected to have the same effects that the brand name Viagra does, because both drugs have the same active ingredient. Therefore, if your doctor has decided that Viagra is safe for you, it means that you can also use Generic Viagra. How does Generic Viagra work? It increases your ability to have and sustain an erection by inhibiting the enzymes that degrade the cyclic guanosine monophosphate, a substance that facilitates the influx of blood into the penis, by relaxing its spongy tissue. In other words, Viagra dilates blood vessels in the penis, and allows the necessary inflow of blood that an erection requires. Viagra can cause erections only when a man is sexually excited. This is the reason why this drug is not for regular use. It should be taken about one hour before sexual activity, and once the sexual intercourse is over the erection goes away. The efficacy of Generic Viagra has been evaluated based on self-assessment questionnaires, and this evaluation has shown that this drug is responsible for the sexual function improvement of almost ninety percent of those who have used it to treat their erectile dysfunctions. The evaluation included firmness, frequency, and ability to maintain an erection; level and frequency of desire; frequency of orgasm; sexual intercourse satisfaction; and relationship satisfaction. When it comes to the side effects that Generic Viagra can have, it is difficult to anticipate them. Your doctor should be informed shortly after the development of a side effect has occurred, or it has changed its intensity. Some of the side effects of Generic Viagra that are more likely to be experienced by those who use it as treatment include headache, abnormal vision, diarrhea, indigestion, urinary tract infection, and nasal congestion. There are other possible side effects, but these have been experienced at a considerably lower frequency. Remember that it is hard to predict how your body will react to this drug. Chances are that you’ll be just fine, if you don’t have a preexisting condition, such as a heart problem. However, you should inform your doctor about any modification that may occur, and he/she will tell you whether or not you should keep taking Generic Viagra. It is the doctor once again that will give you the most detailed information about the food and drugs Generic Viagra interacts with. It is a well-known fact that erectile dysfunction drugs should not be used simultaneously unless prescribed by a doctor. However, Generic Viagra may interact with other drugs as well, which is why you have to consult with your doctor before taking this medicine. He or she will also inform you about the special warnings that come with this medication, and what conditions do not allow the use of Generic Viagra. cialis generic lowest price viagra Cialis relaxes the muscles within the penis which allows enhanced blood flow to achieve and maintain an erection. Cialis is basically used to treat impotence. Cialis’ adverse effects mainly center around headaches which constitute the major chunk among patients, approximately about 11% - 15%. Dyspepsia comes distant second with 4% - 10%. Back pain (3% - 6%), myalgia (1% - 4%), flushing (2% - 3%) and pain in limb (1% - 3%) are the other adverse effects common among the patients opting for Cialis. Many serious cardiovascular events have come into view with the use of Cialis. Problems noted include: myocardial infarction, sudden cardiac death, stroke, chest pain, palpitations and tachycardia. Many of these arise during or shortly after sex or shortly after the use of Cialis without sexual routine. It is next to impossible to judge whether these kinds of events have some association with Cialis, or if they are due to the sexual routine or the patient's underlying cardiovascular disease. There is a small portion of individuals who has have lost eyesight in one eye after taking Cialis. This kind of vision loss is commonly known as non-arteritic anterior ischemic optic neuropathy (NAION). In medical terms, NAION causes a sudden loss of eyesight because blood flow is blocked from the optic nerve. It is not clear at this point in time if Cialis causes NAION, but initial indications depict that Cialis does affect eyesight. To avoid the adverse effects of Cialis, it is of utmost importance that you take it as directed by your health care provider. Take each dose of Cialis with a full glass of water, do not take Cialis more often than directed and never with alcohol which can enhance the risk of headache, dizziness and increased heart rate when Cialis is taken. Apart from that, if you feel dizziness, nausea, or angina (pain, tightness, discomfort, numbness, or tingling in the chest, arms, neck, or jaw) during sex, it is recommended that you refrain from further intercourse and immediately notify your health care provider. As is the case with any other drug, overdose can have a significant bearing on your health. Last but certainly not least, immediately contact your doctor for any erection that lasts for more than 4 hours because an extended erection can damage the penis. viagra online pharmacy Both the drugs enhance blood flow to the groin area. The major point of difference is that Cialis remains effective for a 36-hour time period, compared to just four hours with Viagra. In addition, Cialis can take effect slightly faster than Viagra. They each take effect in up to 30 minutes, give or take a few minutes. The best part about Cialis is that it offers the couple more flexibility. You should remember that both of these male impotence drugs have restrictions. First and foremost, men with a high risk of heart attack or stroke should not use them. Also, potential side effects include back pain and muscle aches with Cialis. People interested in using these drugs should read Consumer Reports on Health which indicates that Viagra has a longer track record because it has been on the market since 1998. Both of the drugs need a doctor's prescription and are rather expensive. Many insurance companies cover the cost of Cialis and Viagra, but it is permitted for a limited supply, normally 4 times a week. If you are not sure which treatment to opt for, it is recommended that you take a look at the causes of impotence and the treatments advised. It is also quite important that you check websites that list all the treatments in comparison to each other to decide which is the best treatment for your situation. Since its inception, Viagra has ruled the erectile dysfunction market, but with the release of drugs like Cialis and Levitra, men have many more options to choose from. There is no hiding the fact that all three have been proven very effective, but it is worth pointing out that there are specific attributes to each drug that you may find suit your requirements. These drugs are in a class known as PDE-5 inhibitors. According to one study, they all have been proven to work in 70% of men with various kinds of erectile dysfunction. They all work in the same way; they need sexual stimulation to activate. Viagra, the oldest of this type of drug, has the fastest acting time. It takes only 14 minutes to be absorbed into the body if taken on an empty stomach. Although Viagra has the quickest acting time, its main disadvantage is the decreased absorption with food take. In a normal scenario, it takes around half an hour for the drug to reach its maximum effect. After that it looses half of its maximum effect every 4 hours. Regarding side effects, a person who uses Viagra can expect mild headaches, upset stomach, unusually bright vision and facial flushing. Cialis, on the other hand, has been approved for duration of 36 hours. Some estimates have even stated that it is effective for up to 100 hours, resulting in the nickname, “the weekender”. to buy viagra how An oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is designated chemically as 1 - [[3 - (6,7 - dihydro - 1 - methyl - 7 - oxo - 3 - propyl - 1H - pyrazolo[4,3 - d]pyrimidin - 5 - yl) - 4 - ethoxyphenyl]sulfonyl] - 4 - methylpiperazine citrate and has the following structural formula: Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7. Viagra (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation. Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels (see ). In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo. Viagra is rapidly absorbed after oral administration, with absolute bioavailability of about 40%. Its pharmacokinetics are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil. The concomitant use of potent cytochrome P450 3A4 inhibitors (e.g., erythromycin, ketoconazole, itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of sildenafil (see ). Both sildenafil and the metabolite have terminal half lives of about 4 hours. in Healthy Male Volunteers. Viagra is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When Viagra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in T of 29%. The mean steady state volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations. Based upon measurements of sildenafil in semen of healthy volunteers 90 minutes after dosing, less than 0.001% of the administered dose may appear in the semen of patients. Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose). Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach. Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, with free plasma concentrations approximately 40% greater than those seen in healthy younger volunteers (18–45 years). In volunteers with mild (CLcr=50–80 mL/min) and moderate (CLcr=30–49 mL/min) renal impairment, the pharmacokinetics of a single oral dose of Viagra (50 mg) were not altered. In volunteers with severe (CLcr=<30 mL/min) renal impairment, sildenafil clearance was reduced, resulting in approximately doubling of AUC and C compared to age-matched volunteers with no renal impairment. In volunteers with hepatic cirrhosis (Child-Pugh A and B), sildenafil clearance was reduced, resulting in increases in AUC (84%) and C (47%) compared to age-matched volunteers with no hepatic impairment. Therefore, age >65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 25 mg should be considered in those patients (see ). In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by an objective measurement of hardness and duration of erections (RigiScan ), after Viagra administration compared with placebo. Most studies assessed the efficacy of Viagra approximately 60 minutes post dose. The erectile response, as assessed by RigiScan , generally increased with increasing sildenafil dose and plasma concentration. The time course of effect was examined in one study, showing an effect for up to 4 hours but the response was diminished compared to 2 hours. Single oral doses of sildenafil (100 mg) administered to healthy volunteers produced decreases in supine blood pressure (mean maximum decrease in systolic/diastolic blood pressure of 8.4/5.5 mmHg). The decrease in blood pressure was most notable approximately 1–2 hours after dosing, and was not different than placebo at 8 hours. Similar effects on blood pressure were noted with 25 mg, 50 mg and 100 mg of Viagra, therefore the effects are not related to dose or plasma levels within this dosage range. Larger effects were recorded among patients receiving concomitant nitrates (see ). Systolic Blood Pressure, Healthy Volunteers. Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. Studies have produced relevant data on the effects of Viagra on cardiac output. In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. A total dose of 40 mg sildenafil was administered by four intravenous infusions. The results from this pilot study are shown in Table 1; the mean resting systolic and diastolic blood pressures decreased by 7% and 10% compared to baseline in these patients. Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28%, 28%, 20% and 7% respectively. Even though this total dosage produced plasma sildenafil concentrations which were approximately 2 to 5 times higher than the mean maximum plasma concentrations following a single oral dose of 100 mg in healthy male volunteers, the hemodynamic response to exercise was preserved in these patients. In a double-blind study, 144 patients with erectile dysfunction and chronic stable angina limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or Viagra 100 mg 1 hour prior to exercise testing. The primary endpoint was time to limiting angina in the evaluable cohort. The mean times (adjusted for baseline) to onset of limiting angina were 423.6 and 403.7 seconds for sildenafil (N=70) and placebo, respectively. These results demonstrated that the effect of Viagra on the primary endpoint was statistically non-inferior to placebo. At single oral doses of 100 mg and 200 mg, transient dose-related impairment of color discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test, with peak effects near the time of peak plasma levels. This finding is consistent with the inhibition of PDE6, which is involved in phototransduction in the retina. An evaluation of visual function at doses up to twice the maximum recommended dose revealed no effects of Viagra on visual acuity, intraocular pressure, or pupillometry. In clinical studies, Viagra was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. Viagra was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover). Viagra was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years. Viagra demonstrated statistically significant improvement compared to placebo in all 21 studies. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. The effectiveness of Viagra was evaluated in most studies using several assessment instruments. The primary measure in the principal studies was a sexual function questionnaire (the International Index of Erectile Function - IIEF) administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment. Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration. The patient addressed both questions at the final visit for the last 4 weeks of the study. The possible categorical responses to these questions were (0) no attempted intercourse, (1) never or almost never, (2) a few times, (3) sometimes, (4) most times, and (5) almost always or always. Also collected as part of the IIEF was information about other aspects of sexual function, including information on erectile function, orgasm, desire, satisfaction with intercourse, and overall sexual satisfaction. Sexual function data were also recorded by patients in a daily diary. In addition, patients were asked a global efficacy question and an optional partner questionnaire was administered. The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 3, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function. Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg. The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse. The titration studies, in which most patients received 100 mg, showed similar results. Figure 3 shows that regardless of the baseline levels of function, subsequent function in patients treated with Viagra was better than that seen in patients treated with placebo. At the same time, on-treatment function was better in treated patients who were less impaired at baseline. Figure 3. Effect of Viagra and Placebo on Maintenance of Erection by Baseline Score. The frequency of patients reporting improvement of erections in response to a global question in four of the randomized, double-blind, parallel, placebo-controlled fixed dose studies (1797 patients) of 12 to 24 weeks duration is shown in Figure 4. These patients had erectile dysfunction at baseline that was characterized by median categorical scores of 2 (a few times) on principal IIEF questions. Erectile dysfunction was attributed to organic (58%; generally not characterized, but including diabetes and excluding spinal cord injury), psychogenic (17%), or mixed (24%) etiologies. Sixty-three percent, 74%, and 82% of the patients on 25 mg, 50 mg and 100 mg of Viagra, respectively, reported an improvement in their erections, compared to 24% on placebo. In the titration studies (n=644) (with most patients eventually receiving 100 mg), results were similar. Figure 4. Percentage of Patients Reporting an Improvement in Erections. The patients in studies had varying degrees of ED. One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period. In many of the studies, of both fixed dose and titration designs, daily diaries were kept by patients. In these studies, involving about 1600 patients, analyses of patient diaries showed no effect of Viagra on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged 1.3 on 50–100 mg of Viagra vs 0.4 on placebo; similarly, group mean success rates (total successes divided by total attempts) were about 66% on Viagra vs about 20% on placebo. During 3 to 6 months of double-blind treatment or longer-term (1 year), open-label studies, few patients withdrew from active treatment for any reason, including lack of effectiveness. At the end of the long-term study, 88% of patients reported that Viagra improved their erections. Men with untreated ED had relatively low baseline scores for all aspects of sexual function measured (again using a 5-point scale) in the IIEF. Viagra improved these aspects of sexual function: frequency, firmness and maintenance of erections; frequency of orgasm; frequency and level of desire; frequency, satisfaction and enjoyment of intercourse; and overall relationship satisfaction. One randomized, double-blind, flexible-dose, placebo-controlled study included only patients with erectile dysfunction attributed to complications of diabetes mellitus (n=268). As in the other titration studies, patients were started on 50 mg and allowed to adjust the dose up to 100 mg or down to 25 mg of Viagra; all patients, however, were receiving 50 mg or 100 mg at the end of the study. There were highly statistically significant improvements on the two principal IIEF questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) on Viagra compared to placebo. On a global improvement question, 57% of Viagra patients reported improved erections versus 10% on placebo. Diary data indicated that on Viagra, 48% of intercourse attempts were successful versus 12% on placebo. One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted. The changes from baseline in scoring on the two end point questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) were highly statistically significantly in favor of Viagra. On a global improvement question, 83% of patients reported improved erections on Viagra versus 12% on placebo. Diary data indicated that on Viagra, 59% of attempts at sexual intercourse were successful compared to 13% on placebo. Across all trials, Viagra improved the erections of 43% of radical prostatectomy patients compared to 15% on placebo. Subgroup analyses of responses to a global improvement question in patients with psychogenic etiology in two fixed-dose studies (total n=179) and two titration studies (total n=149) showed 84% of Viagra patients reported improvement in erections compared with 26% of placebo. The changes from baseline in scoring on the two end point questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) were highly statistically significantly in favor of Viagra. Diary data in two of the studies (n=178) showed rates of successful intercourse per attempt of 70% for Viagra and 29% for placebo. A review of population subgroups demonstrated efficacy regardless of baseline severity, etiology, race and age. Viagra was effective in a broad range of ED patients, including those with a history of coronary artery disease, hypertension, other cardiac disease, peripheral vascular disease, diabetes mellitus, depression, coronary artery bypass graft (CABG), radical prostatectomy, transurethral resection of the prostate (TURP) and spinal cord injury, and in patients taking antidepressants/antipsychotics and antihypertensives/diuretics. Analysis of the safety database showed no apparent difference in the side effect profile in patients taking Viagra with and without antihypertensive medication. This analysis was performed retrospectively, and was not powered to detect any pre-specified difference in adverse reactions. Viagra is indicated for the treatment of erectile dysfunction. ), Viagra was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using organic nitrates, either regularly and/or intermittently, in any form is therefore contraindicated. After patients have taken Viagra, it is unknown when nitrates, if necessary, can be safely administered. Based on the pharmacokinetic profile of a single 100 mg oral dose given to healthy normal volunteers, the plasma levels of sildenafil at 24 hours post dose are approximately 2 ng/mL (compared to peak plasma levels of approximately 440 ng/mL) (see ). In the following patients: age >65, hepatic impairment (e.g., cirrhosis), severe renal impairment (e.g., creatinine clearance <30 mL/min), and concomitant use of potent cytochrome P450 3A4 inhibitors (erythromycin), plasma levels of sildenafil at 24 hours post dose have been found to be 3 to 8 times higher than those seen in healthy volunteers. Although plasma levels of sildenafil at 24 hours post dose are much lower than at peak concentration, it is unknown whether nitrates can be safely coadministered at this time point. Viagra is contraindicated in patients with a known hypersensitivity to any component of the tablet. There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. Therefore, treatments for erectile dysfunction, including Viagra, should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status. Viagra has systemic vasodilatory properties that resulted in transient decreases in supine blood pressure in healthy volunteers (mean maximum decrease of 8.4/5.5 mmHg), (see ). While this normally would be expected to be of little consequence in most patients, prior to prescribing Viagra, physicians should carefully consider whether their patients with underlying cardiovascular disease could be affected adversely by such vasodilatory effects, especially in combination with sexual activity. Patients with the following underlying conditions can be particularly sensitive to the actions of vasodilators including Viagra – those with left ventricular outflow obstruction (e.g. aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure. There is no controlled clinical data on the safety or efficacy of Viagra in the following groups; if prescribed, this should be done with caution. Patients who have suffered a myocardial infarction, stroke, or life-threatening arrhythmia within the last 6 months; Patients with retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases). Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result. The concomitant administration of the protease inhibitor ritonavir substantially increases serum concentrations of sildenafil (11-fold increase in AUC). If Viagra is prescribed to patients taking ritonavir, caution should be used. Data from subjects exposed to high systemic levels of sildenafil are limited. Visual disturbances occurred more commonly at higher levels of sildenafil exposure. Decreased blood pressure, syncope, and prolonged erection were reported in some healthy volunteers exposed to high doses of sildenafil (200–800 mg). To decrease the chance of adverse events in patients taking ritonavir, a decrease in sildenafil dosage is recommended (see , ). The evaluation of erectile dysfunction should include a determination of potential underlying causes and the identification of appropriate treatment following a complete medical assessment. Before prescribing Viagra, it is important to note the following: Caution is advised when Phosphodiesterase Type 5 (PDE5) inhibitors are co-administered with alpha-blockers. PDE5 inhibitors, including Viagra, and alpha-adrenergic blocking agents are both vasodilators with blood pressure lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. In some patients, concomitant use of these two drug classes can lower blood pressure significantly (see ) leading to symptomatic hypotension (e.g. dizziness, lightheadedness, fainting). Patients should be stable on alpha-blocker therapy prior to initiating a PDE5 inhibitor. Patients who demonstrate hemodynamic instability on alpha-blocker therapy alone are at increased risk of symptomatic hypotension with concomitant use of PDE5 inhibitors. In those patients who are stable on alpha-blocker therapy, PDE5 inhibitors should be initiated at the lowest dose. In those patients already taking an optimized dose of a PDE5 inhibitor, alpha-blocker therapy should be initiated at the lowest dose. Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure when taking a PDE5 inhibitor. Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other anti-hypertensive drugs. Viagra has systemic vasodilatory properties and may augment the blood pressure lowering effect of other anti-hypertensive medications. Patients on multiple antihypertensive medications were included in the pivotal clinical trials for Viagra. In a separate drug interaction study, when amlodipine, 5 mg or 10 mg, and Viagra, 100 mg were orally administered concomitantly to hypertensive patients mean additional blood pressure reduction of 8 mmHg systolic and 7 mmHg diastolic were noted (see ). The safety of Viagra is unknown in patients with bleeding disorders and patients with active peptic ulceration. Viagra should be used with caution in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie's disease), or in patients who have conditions which may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia). The safety and efficacy of combinations of Viagra with other treatments for erectile dysfunction have not been studied. Therefore, the use of such combinations is not recommended. In humans, Viagra has no effect on bleeding time when taken alone or with aspirin. In vitro studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside (a nitric oxide donor). The combination of heparin and Viagra had an additive effect on bleeding time in the anesthetized rabbit, but this interaction has not been studied in humans. Physicians should discuss with patients the contraindication of Viagra with regular and/or intermittent use of organic nitrates. Physicians should advise patients of the potential for Viagra to augment the blood pressure lowering effect of alpha-blockers and anti-hypertensive medications. Concomitant administration of Viagra and an alpha-blocker may lead to symptomatic hypotension in some patients. Therefore, when Viagra is co-administered with alpha-blockers, patients should be stable on alpha-blocker therapy prior to initiating Viagra treatment and Viagra should be initiated at the lowest dose. Physicians should discuss with patients the potential cardiac risk of sexual activity in patients with preexisting cardiovascular risk factors. Patients who experience symptoms (e.g., angina pectoris, dizziness, nausea) upon initiation of sexual activity should be advised to refrain from further activity and should discuss the episode with their physician. Physicians should advise patients to stop use of all PDE5 inhibitors, including Viagra, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, that has been reported rarely post-marketing in temporal association with the use of all PDE5 inhibitors. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. Physicians should also discuss with patients the increased risk of NAION in individuals who have already experienced NAION in one eye, including whether such individuals could be adversely affected by use of vasodilators, such as PDE5 inhibitors (see ). Physicians should advise patients to stop taking PDE5 inhibitors, including Viagra, and seek prompt medical attention in the event of sudden decrease or loss of hearing. These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including Viagra. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors (see , ). Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result. The use of Viagra offers no protection against sexually transmitted diseases. Counseling of patients about the protective measures necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), may be considered. Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route). Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance. Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increase in plasma sildenafil concentrations when coadministered with Viagra (50 mg) to healthy volunteers. When a single 100 mg dose of Viagra was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in sildenafil systemic exposure (AUC). In addition, in a study performed in healthy male volunteers, coadministration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with Viagra (100 mg single dose) resulted in a 140% increase in sildenafil C and a 210% increase in sildenafil AUC. Viagra had no effect on saquinavir pharmacokinetics. Stronger CYP3A4 inhibitors such as ketoconazole or itraconazole would be expected to have still greater effects, and population data from patients in clinical trials did indicate a reduction in sildenafil clearance when it was coadministered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine) (see ). In another study in healthy male volunteers, coadministration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with Viagra (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil C and a 1000% (11-fold) increase in sildenafil plasma AUC. At 24 hours the plasma levels of sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed alone. This is consistent with ritonavir's marked effects on a broad range of P450 substrates. Viagra had no effect on ritonavir pharmacokinetics (see ). Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels. In a study of healthy male volunteers, co-administration of sildenafil at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of cytochrome P450 2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of sildenafil AUC and a 55% decrease in sildenafil C . Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil. Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of Viagra. Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors (such as tolbutamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence. Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 µM). Given sildenafil peak plasma concentrations of approximately 1 µM after recommended doses, it is unlikely that Viagra will alter the clearance of substrates of these isoenzymes. Three double-blind, placebo-controlled, randomized, two-way crossover studies were conducted to assess the interaction of Viagra with doxazosin, an alpha-adrenergic blocking agent. In the first study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 2-period crossover design to 4 generally healthy males with benign prostatic hyperplasia (BPH). Following at least 14 consecutive daily doses of doxazosin, Viagra 100 mg or matching placebo was administered simultaneously with doxazosin. Following a review of the data from these first 4 subjects (details provided below), the Viagra dose was reduced to 25 mg. Thereafter, 17 subjects were treated with Viagra 25 mg or matching placebo in combination with doxazosin 4 mg (15 subjects) or doxazosin 8mg (2 subjects). The mean subject age was 66.5 years. For the 17 subjects who received Viagra 25 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.5, 2, 2.5, 3, 4, 6 and 8 hours after Viagra or matching placebo. Outliers were defined as subjects with a standing systolic blood pressure of <85 mmHg or a decrease from baseline in standing systolic blood pressure of >30 mmHg at one or more timepoints. There were no subjects treated with Viagra 25 mg who had a standing SBP < 85mmHg. There were three subjects with a decrease from baseline in standing systolic BP >30mmHg following Viagra 25 mg, one subject with a decrease from baseline in standing systolic BP > 30 mmHg following placebo and two subjects with a decrease from baseline in standing systolic BP > 30 mmHg following both Viagra and placebo. No severe adverse events potentially related to blood pressure effects were reported in this group. Of the four subjects who received Viagra 100 mg in the first part of this study, a severe adverse event related to blood pressure effect was reported in one patient (postural hypotension that began 35 minutes after dosing with Viagra with symptoms lasting for 8 hours), and mild adverse events potentially related to blood pressure effects were reported in two others (dizziness, headache and fatigue at 1 hour after dosing; and dizziness, lightheadedness and nausea at 4 hours after dosing). There were no reports of syncope among these patients. For these four subjects, the placebo-subtracted mean maximum decreases from baseline in supine and standing systolic blood pressures were 14.8 mmHg and 21.5 mmHg, respectively. Two of these subjects had a standing SBP < 85mmHg. Both of these subjects were protocol violators, one due to a low baseline standing SBP, and the other due to baseline orthostatic hypotension. In the second study, a single oral dose of Viagra 50 mg or matching placebo was administered in a 2-period crossover design to 20 generally healthy males with BPH. Following at least 14 consecutive days of doxazosin, Viagra 50mg or matching placebo was administered simultaneously with doxazosin 4 mg (17 subjects) or with doxazosin 8 mg (3 subjects). The mean subject age in this study was 63.9 years. Twenty subjects received Viagra 50 mg, but only 19 subjects received matching placebo. One patient discontinued the study prematurely due to an adverse event of hypotension following dosing with Viagra 50 mg. This patient had been taking minoxidil, a potent vasodilator, during the study. For the 19 subjects who received both Viagra and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured after administration of Viagra at the same times as those specified for the first doxazosin study. There were two subjects who had a standing SBP of < 85 mmHg. In these two subjects, hypotension was reported as a moderately severe adverse event, beginning at approximately 1 hour after administration of Viagra 50 mg and resolving after approximately 7.5 hours. There was one subject with a decrease from baseline in standing systolic BP >30mmHg following Viagra 50 mg and one subject with a decrease from baseline in standing systolic BP > 30 mmHg following both Viagra 50 mg and placebo. There were no severe adverse events potentially related to blood pressure and no episodes of syncope reported in this study. In the third study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 3-period crossover design to 20 generally healthy males with BPH. In dose period 1, subjects were administered open-label doxazosin and a single dose of Viagra 50 mg simultaneously, after at least 14 consecutive days of doxazosin. If a subject did not successfully complete this first dosing period, he was discontinued from the study. Subjects who had successfully completed the previous doxazosin interaction study (using Viagra 50 mg), including no significant hemodynamic adverse events, were allowed to skip dose period 1. Treatment with doxazosin continued for at least 7 days after dose period 1. Thereafter, Viagra 100mg or matching placebo was administered simultaneously with doxazosin 4 mg (14 subjects) or doxazosin 8 mg (6 subjects) in standard crossover fashion. The mean subject age in this study was 66.4 years. Twenty-five subjects were screened. Two were discontinued after study period 1: one failed to meet pre-dose screening qualifications and the other experienced symptomatic hypotension as a moderately severe adverse event 30 minutes after dosing with open-label Viagra 50 mg. Of the twenty subjects who were ultimately assigned to treatment, a total of 13 subjects successfully completed dose period 1, and seven had successfully completed the previous doxazosin study (using Viagra 50 mg). For the 20 subjects who received Viagra 100 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured after administration of Viagra at the same times as those specified for the previous doxazosin studies. There were three subjects who had a standing SBP of < 85 mmHg. All three were taking Viagra 100 mg, and all three reported mild adverse events at the time of reductions in standing SBP, including vasodilation and lightheadedness. There were four subjects with a decrease from baseline in standing systolic BP >30mmHg following Viagra 100 mg, one subject with a decrease from baseline in standing systolic BP > 30 mmHg following placebo and one subject with a decrease from baseline in standing systolic BP > 30 mmHg following both Viagra and placebo. While there were no severe adverse events potentially related to blood pressure reported in this study, one subject reported moderate vasodilatation after both Viagra 50 mg and 100 mg. There were no episodes of syncope reported in this study. When Viagra 100 mg oral was coadministered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic. No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9. Viagra (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg). Viagra (50 mg) did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.08%. In a study of healthy male volunteers, sildenafil (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Sildenafil at steady state (80 mg t.i.d.) resulted in a 50% increase in AUC and a 42% increase in C of bosentan (125 mg b.i.d.). Carcinogenesis, Mutagenesis, Impairment of Fertility Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29- and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg. Sildenafil was not carcinogenic when administered to mice for 18–21 months at dosages up to the Maximum Tolerated Dose (MTD) of 10 mg/kg/day, approximately 0.6 times the MRHD on a mg/m basis. Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity. There was no impairment of fertility in rats given sildenafil up to 60 mg/kg/day for 36 days to females and 102 days to males, a dose producing an AUC value of more than 25 times the human male AUC. There was no effect on sperm motility or morphology after single 100 mg oral doses of Viagra in healthy volunteers. Pregnancy, Nursing Mothers and Pediatric Use Viagra is not indicated for use in newborns, children, or women. No evidence of teratogenicity, embryotoxicity or fetotoxicity was observed in rats and rabbits which received up to 200 mg/kg/day during organogenesis. These doses represent, respectively, about 20 and 40 times the MRHD on a mg/m basis in a 50 kg subject. In the rat pre- and postnatal development study, the no observed adverse effect dose was 30 mg/kg/day given for 36 days. In the nonpregnant rat the AUC at this dose was about 20 times human AUC. There are no adequate and well-controlled studies of sildenafil in pregnant women. ). Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered (see ). Viagra was administered to over 3700 patients (aged 19–87 years) during pre-marketing clinical trials worldwide. Over 550 patients were treated for longer than one year. In placebo-controlled clinical studies, the discontinuation rate due to adverse events for Viagra (2.5%) was not significantly different from placebo (2.3%). The adverse events were generally transient and mild to moderate in nature. In trials of all designs, adverse events reported by patients receiving Viagra were generally similar. In fixed-dose studies, the incidence of some adverse events increased with dose. The nature of the adverse events in flexible-dose studies, which more closely reflect the recommended dosage regimen, was similar to that for fixed-dose studies. When Viagra was taken as recommended (on an as-needed basis) in flexible-dose, placebo-controlled clinical trials, the following adverse events were reported: Other adverse reactions occurred at a rate of >2%, but equally common on placebo: respiratory tract infection, back pain, flu syndrome, and arthralgia. In fixed-dose studies, dyspepsia (17%) and abnormal vision (11%) were more common at 100 mg than at lower doses. At doses above the recommended dose range, adverse events were similar to those detailed above but generally were reported more frequently. The following events occurred in <2% of patients in controlled clinical trials; a causal relationship to Viagra is uncertain. Reported events include those with a plausible relation to drug use; omitted are minor events and reports too imprecise to be meaningful: Body as a whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury. Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy. Digestive: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis. Hemic and Lymphatic: anemia and leukopenia. Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia. Musculoskeletal: arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis. Nervous: ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia. Respiratory: asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased. Skin and Appendages: urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis. Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes. Urogenital: cystitis, nocturia, urinary frequency, breast enlargement, urinary incontinence, abnormal ejaculation, genital edema and anorgasmia. Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of Viagra. Most, but not all, of these patients had preexisting cardiovascular risk factors. Many of these events were reported to occur during or shortly after sexual activity, and a few were reported to occur shortly after the use of Viagra without sexual activity. Others were reported to have occurred hours to days after the use of Viagra and sexual activity. It is not possible to determine whether these events are related directly to Viagra, to sexual activity, to the patient's underlying cardiovascular disease, to a combination of these factors, or to other factors (see for further important cardiovascular information). Cases of sudden decrease or loss of hearing have been reported postmarketing in temporal association with the use of PDE5 inhibitors, including Viagra. In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. In many cases, medical follow-up information was limited. It is not possible to determine whether these reported events are related directly to the use of Viagra, to the patient’s underlying risk factors for hearing loss, a combination of these factors, or to other factors (see ). Nervous: seizure and anxiety. Urogenital: prolonged erection, priapism (see ), and hematuria. Special Senses: diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal vascular disease or bleeding, vitreous detachment/traction, paramacular edema and epistaxis. Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported rarely post-marketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including Viagra. Most, but not all, of these patients had underlying anatomic or vascular risk factors for developing NAION, including but not necessarily limited to: low cup to disc ratio ("crowded disc"), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors, to the patient's underlying vascular risk factors or anatomical defects, to a combination of these factors, or to other factors (see ). In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine. For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Viagra may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day. The following factors are associated with increased plasma levels of sildenafil: age >65 (40% increase in AUC), hepatic impairment (e.g., cirrhosis, 80%), severe renal impairment (creatinine clearance <30 mL/min, 100%), and concomitant use of potent cytochrome P450 3A4 inhibitors [ketoconazole, itraconazole, erythromycin (182%), saquinavir (210%)]. Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients. Ritonavir greatly increased the systemic level of sildenafil in a study of healthy, non-HIV infected volunteers (11-fold increase in AUC, see .) Based on these pharmacokinetic data, it is recommended not to exceed a maximum single dose of 25 mg of Viagra in a 48 hour period. Viagra was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated. When Viagra is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating Viagra treatment and Viagra should be initiated at the lowest dose (see ). Viagra (sildenafil citrate) is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to the nominally indicated amount of sildenafil as follows: Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F) [see USP Controlled Room Temperature]. LAB-0221-8.0 ®. It is not meant to take the place of your doctor's instructions. Read this information carefully before you start taking Viagra. Ask your doctor or pharmacist if you do not understand any of this information or if you want to know more about Viagra. This medicine can help many men when it is used as prescribed by their doctors. However, Viagra is not for everyone. It is intended for use only by men who have a condition called erectile dysfunction. Viagra must never be used by men who are taking medicines that contain nitrates of any kind, at any time. This includes nitroglycerin. If you take Viagra with any nitrate medicine your blood pressure could suddenly drop to an unsafe or life threatening level. • WHAT IS Viagra? Viagra is a pill used to treat erectile dysfunction (impotence) in men. It can help many men who have erectile dysfunction get and keep an erection when they become sexually excited (stimulated). You will not get an erection just by taking this medicine. Viagra helps a man with erectile dysfunction get an erection only when he is sexually excited. When a man is sexually excited, the penis rapidly fills with more blood than usual. The penis then expands and hardens. This is called an erection. After the man is done having sex, this extra blood flows out of the penis back into the body. The erection goes away. If an erection lasts for a long time (more than 6 hours), it can permanently damage your penis. You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours. Some conditions and medicines interfere with this natural erection process. The penis cannot fill with enough blood. The man cannot have an erection. This is called erectile dysfunction if it becomes a frequent problem. During sex, your heart works harder. Therefore sexual activity may not be advisable for people who have heart problems. Before you start any treatment for erectile dysfunction, ask your doctor if your heart is healthy enough to handle the extra strain of having sex. If you have chest pains, dizziness or nausea during sex, stop having sex and immediately tell your doctor you have had this problem. Viagra enables many men with erectile dysfunction to respond to sexual stimulation. When a man is sexually excited, Viagra helps the penis fill with enough blood to cause an erection. After sex is over, the erection goes away. As noted above (How Sex Affects the Body), ask your doctor if your heart is healthy enough for sexual activity. If you take any medicines that contain nitrates – either regularly or as needed – you should never take Viagra. If you take Viagra with any nitrate medicine or recreational drug containing nitrates, your blood pressure could suddenly drop to an unsafe level. You could get dizzy, faint, or even have a heart attack or stroke. Nitrates are found in many prescription medicines that are used to treat angina (chest pain due to heart disease) such as: nitroglycerin (sprays, ointments, skin patches or pastes, and tablets that are swallowed or dissolved in the mouth) isosorbide mononitrate and isosorbide dinitrate (tablets that are swallowed, chewed, or dissolved in the mouth) Nitrates are also found in recreational drugs such as amyl nitrate or nitrite ("poppers"). If you are not sure if any of your medicines contain nitrates, or if you do not understand what nitrates are, ask your doctor or pharmacist. Viagra is only for patients with erectile dysfunction. Viagra is not for newborns, children, or women. Do not let anyone else take your Viagra. Viagra must be used only under a doctor's supervision. Viagra does not cure erectile dysfunction. It is a treatment for erectile dysfunction. Viagra does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS. Viagra is not a hormone or an aphrodisiac. Only your doctor can decide if Viagra is right for you. Viagra can cause mild, temporary lowering of your blood pressure. You will need to have a thorough medical exam to diagnose your erectile dysfunction and to find out if you can safely take Viagra alone or with your other medicines. Your doctor should determine if your heart is healthy enough to handle the extra strain of having sex. have ever had any heart problems (e.g., angina, chest pain, heart failure, irregular heart beats, heart attack or narrowing of the aortic valve) have ever had any blood problems, including sickle cell anemia or leukemia have a deformed penis, Peyronie's disease, or ever had an erection that lasted more than 4 hours Some medicines can change the way Viagra works. Tell your doctor about any medicines you are taking. Do not start or stop taking any medicines before checking with your doctor or pharmacist. This includes prescription and nonprescription medicines or remedies: Remember, Viagra should never be used with medicines that contain nitrates (see Viagra Is Not for Everyone). If you are taking medicines called alpha-blockers for the treatment of high blood pressure or prostate problems, your blood pressure could suddenly drop. You could get dizzy or faint. If you are taking a protease inhibitor, your dose may be adjusted (please see Finding the Right Dose for You). Viagra should not be used with any other medical treatments that cause erections. These treatments include pills, medicines that are injected or inserted into the penis, implants or vacuum pumps. Viagra comes in different doses (25 mg, 50 mg and 100 mg). If you do not get the results you expect, talk with your doctor. You and your doctor can determine the dose that works best for you. Do not take more Viagra than your doctor prescribes. If you think you need a larger dose of Viagra, check with your doctor. Viagra should not be taken more than once a day. Your doctor may prescribe a lower dose of Viagra in certain circumstances. For example: If you are older than age 65, or have serious liver or kidney problems, your doctor may start you at the lowest dose (25 mg) of Viagra. If you are taking protease inhibitors, such as for the treatment of HIV, your doctor may recommend a 25 mg dose and may limit you to a maximum single dose of 25 mg of Viagra in a 48 hour period. If you have prostate problems or high blood pressure for which you take medicines called alpha blockers, your doctor may start you on a lower dose of Viagra. Take Viagra about one hour before you plan to have sex. Beginning in about 30 minutes and for up to 4 hours, Viagra can help you get an erection if you are sexually excited. If you take Viagra after a high-fat meal (such as a cheeseburger and french fries), the medicine may take a little longer to start working. Viagra can help you get an erection when you are sexually excited. You will not get an erection just by taking the pill. Like all medicines, Viagra can cause some side effects. These effects are usually mild to moderate and usually don't last longer than a few hours. Some of these side effects are more likely to occur with higher doses. The most common side effects of Viagra are headache, flushing of the face, and upset stomach. Less common side effects that may occur are temporary changes in color vision (such as trouble telling the difference between blue and green objects or having a blue color tinge to them), eyes being more sensitive to light, or blurred vision. In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including Viagra) reported a sudden decrease or loss of vision in one or both eyes. It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including Viagra, and call a doctor right away. In rare instances, men have reported an erection that lasts many hours. You should call a doctor immediately if you ever have an erection that lasts more than 4 hours. If not treated right away, permanent damage to your penis could occur (see How Sex Affects the Body). Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been rarely reported in people taking PDE5 inhibitors, including Viagra. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking Viagra and contact a doctor right away. Heart attack, stroke, irregular heart beats, and death have been reported rarely in men taking Viagra. Most, but not all, of these men had heart problems before taking this medicine. It is not possible to determine whether these events were directly related to Viagra. Viagra may cause other side effects besides those listed on this sheet. If you want more information or develop any side effects or symptoms you are concerned about, call your doctor. In case of accidental overdose, call your doctor right away. Keep Viagra out of the reach of children. Keep Viagra in its original container. Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F) [see USP Controlled Room Temperature]. Viagra is a prescription medicine used to treat erectile dysfunction. Only your doctor can decide if it is right for you. This sheet is only a summary. If you have any questions or want more information about Viagra, talk with your doctor or pharmacist, visit www.Viagra.com, or call 1-888-4Viagra. LAB-0220-6.0levitra viagra comparison Message copied & clipped from an e-mail we recieved from a more than happy customer. Wow what can I say… an amazing experience. In August a couple of my friends and I had planned to go on a short break to Amsterdam to unwind from stress and worries of our normal lives. We already had lots of things planned to do while we were there but once we arrived we were suprised to see one of our mates had brought along ). I personally hadn’t tried this stuff before, but I was always anxious when joining a female in the ‘bedroom department’ just incase I under performed so the thought of buying viagra or a viagra alternative had always crossed my mind but I just simply didn’t get around to it. This made me quite excited to use it. On the second night of being there, our mate suggested for us to go to a strip bar and as you can imagine we hit bar after bar and ended up in you know where. My mate pulled out the strip of kamagra jellys and we got down to business! My friend who brought the kamagra originally gave me your website address so I could buy some more at a later date. So I decided to e-mail you guys with a short story of my experience of generic viagra. Oh and yes, the sex was amazing!| 2003 cyalis levitra market sales viagra
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HE is only two, but Oliver Sherwood regularly takes Viagra - to keep him alive. The toddler has a rare condition that causes chronic high blood pressure. Something as simple a chest infection could kill him. The pulmonary hypertension, as it is known, can be controlled with four doses of Viagra a day. The drug improves blood flow, which in adults can boost erectile function but in rare cases such as Oliver's can open the veins and capillaries to aid circulation. His mother Sarah, a part-time nurse, said: "We joke when we pick up his drugs that it would be Christmas come early for most people. Obviously the dose isn't high enough to have the effect it would on adults. "Viagra is an expensive drug but it's actually one of the cheapest to treat pulmonary hypertension. "We're just hoping it'll continue to work as he grows a bit older." But Oliver's future could be in doubt because other drugs he could use as he gets older might no longer be funded by the Health Service. Pulmonary hypertension causes the blood pressure in the arteries in the lungs to rise, straining the heart and reducing blood oxygen levels, causing breathlessness and exhaustion. Symptoms include severe coughing and breathing problems as blood fills the lungs, constant nose bleeds, dizziness and chest pains. The condition, which affects 4,000 in Britain, often leads to heart failure. It is so rare that only five children a year are diagnosed with it in the UK. The survival rate is around five years, even with medication such as Oliver, who cannot walk more than a few steps without getting out of breath, takes one tablet of Sildenafil crushed into four 5ml doses a day. Doctors can increase the dose when his condition worsens, but there is no way of telling how much longer the drugs will be effective. As he grows up he will need to switch to more expensive treatments called Epoprostenol and Iloprost to control his condition. But the Government's drug rationing agency, the National Institute for Health and Clinical Excellence, is considering whether to continue prescribing them. Oliver's mother has started a petition calling for the Health Service to keep funding the treatments. Mrs Sherwood, 34, of Hucclecote, Gloucestershire, said: "The only hope we had was that he would be maintained through medication but if anything-happens in the future that hope may be taken away." The Pulmonary Hypertension Association said: "The clinical evidence for this is unfounded and it must be assumed it is based on cost alone." A spokesman for NICE added: "Our review of the evidence suggests that Sildenafil is both clinically effective and cost-effective in treating pulmonary arterial hypertension.".
Jetlag is defined as a temporary disturbance of the bodily rhythms which is caused by high-speed travel, whether it is on land or on air and across various time zone. this disturbance is usually common in jet aircrafts. people who cross various time zones find it easier to recover from jet lag if the purpose of the travel is for a vacation. this is because when a person travels to a place where he is allowed to relax and recover slowly, it gives him the chance to adjust to the local time of the area. but there are also persons who are not that lucky. people who travel for business purposes usually cross a lot of time zones. when the business traveler reaches his destination he gets busy attending meetings and doing the work that has to be done all based on the local time of that certain place. thus the business travelers cannot afford the luxury of relaxing and adjusting their bodies to the place's local time. can viagra be a relief for jetlag? it is usually not known that there is a certain link between jetlag and viagra. a recent study has shown that not only does viagra treat erectile dysfunction but it can actually also neutralize the effects of jetlag. viagra has been observed to restore normal bodily clock functions which have been shifted by six hours. viagra was first developed by pfizer for aid in treatment of angina and high blood pressure by disturbing the enzyme that causes the reduction of cgmp, a natural compound, cgmp plays a very important in the function of penile erection. in relation to jetlag, cgmp acts in a region of the brain whose role is to regulate the circadian cycle. the circadian cycle is the body's internal clock that determines the waning and the waxing of hormones and also controls the urge to sleep and wake. in a laboratory test, hamsters were injected with viagra and subjected to bright lights for 6 hours ahead of the regular time. they were observed by a team of researchers from the universidad nacional de quilmes. they found that the injected hamsters have improved in coping with the time difference by 25 to 50 percent as those compared to the hamsters that were not administered with viagra. the testing gave out a positive result in the light to dark cycle which is the equivalent of traveling from west to east. further test is needed to really identify the possibility of viagra as an effective treatment to counter the ill feeling of traveler's jetlag. if this can be validated, then the blue pill can cross the barrier of time and human dysfunction. The most widely used remedy for erectile dysfunction; research has indicated that Viagra has an effect on the condition of the human heart as well as a male's penis. The hormonal stress normally exerted on the human heart has been noted to be decreased in men who take Viagra. When conducted with mice, the testing was more noticeable, Viagra having the tendency to avert harmful and long term effects of chronic hypertension on their heart. The study, lead by the John Hopkins research team, found that there is potential benefits for the treatment of pulmonary hypertension, linked in with how Viagra dilates genital blood vessels. Viagra works by dulling the heart beat, which is increased during stress. It works to decrease the force which is needed to pump blood from the heart to the rest of the body. The research conducted by David Kass, cardiologist and senior researcher of the John Hopkins study noticed Viagra can be effective in blocking short- term consequences of hormonal stresses in the heart. Further evidence on the testing of mice (although further research is needed until this is applicable to humans), indicated that negative effects of heart failure and cardiac hypertrophy on weakened heart muscles can be reversed. Further research is need in this area on humans however. Thirty five men and women were tested and injected with Dobutamine (a synthetic derivative of dopamine that increases heart rate and contractions), which resulted in increased rate of 150%. The men and women were then separated into two groups, one of which were given sildenafil (Viagra) and the other given a placebo (fake) pill. Results showed that the first group's heart rate decreased by 50%, whilst the latter group's further increased. This has led to widespread scientific interest in the effects of sildenafil (Viagra) on the human heart condition.cialis generico sildenafil What is Viagra used for? Viagra is used to treat impotence in men. Viagra increases the body’s ability to achieve and maintain an erection during sexual stimulation. Viagra does not protect you from getting sexually transmitted diseases, including HIV. take Viagra? Men who are currently using medicines that contain nitrates, such as nitroglycerin should not use Viagra because taken together they can lower the blood pressure too much. Viagra should not be used by women or children. In patients taking Viagra, several heart-related side effects have been reported, including heart attack, sudden death, irregular heart rhythm, stroke, chest pain, and increased blood pressure. It is not possible to determine whether these events are directly related to Viagra, to sexual activity, to the patient’s heart condition, to a combination of these factors, or to other factors. taking certain medications at the same time (e.g., ketoconazole, itraconazole, erythromycin and saquinavir). In these patients, the recommended starting dose of Viagra is 25 mg. Heart attack, stroke, or life-threatening irregular heart rhythm within the last 6 months Because Viagra lowers blood pressure, your doctor will evaluate your overall medical condition to determine if Viagra, in combination with sexual activity, could adversely affect you. Viagra can cause a rare but serious condition of prolonged erection (priapism). It is important to contact your health care provider immediately if your erection lasts longer than 4 hours. Men for whom sexual activity is inadvisable may not be good candidates for Viagra. Tell your doctor if you are taking protease inhibitors for the treatment of HIV. You should have a complete medical history and exam to determine the cause of your impotence before taking Viagra. Men who have medical conditions that may cause a sustained erection such as sickle cell anemia, leukemia or multiple myeloma or who have an abnormally shaped penis may not be able to take Viagra. There are several medications that are known to interact with Viagra, so be sure to tell your doctor about all medications you are taking including those you can get without a prescription. Viagra has not been studied with other treatments for impotence, so use in combination with other treatments is not recommended. What are some possible side effects of Viagra? a complete list of side effects reported with Viagra. Your health care provider can discuss with you a more complete list of side effects.) ). The following is a listing of the most common side effects Visual changes such as mild and temporary changes in blue/green colors or increased sensitivity to light. 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Money Back Guarantee if not 100% Satisfied. All orders received before 2pm GMT will be dispatched same day from the UK. Postage is free. sales genuine viagra Why pay £20 per tablet via your Doctor’s Prescription? You can now get 4 x Genuine 20mg (DOUBLE STRENGTH!) Cialis Tablets DIRECT at these LOW LOW PRICES! Genuine 20mg (DOUBLE STRENGTH!) Cialis Tablets give YOU rock hard erections every time! You just take HALF A TABLET 30-60 minutes before any sexual activity. (THIS GIVES YOU 8 TOTAL DOSES!) We have this product in stock sealed, hologrammed boxes of 4 x Cialis 20mg. Expiry date is December 2010. Yes, i like viagra, cialis and Sex 5 cheap sildenafil citrate Generic Viagra is a drug used for erectile dysfunctions, or male impotence, and it represents the name for a substance known as sildenafil citrate. The substance is the same, while the market name of the drug may vary and so may its price. Generic versions for many types of drugs have been around for quite some time, but Generic Viagra is a fairly new drug on the market, and it gives men a chance at treating their erectile dysfunctions in an affordable way. Generic Viagra can be expected to have the same effects that the brand name Viagra does, because both drugs have the same active ingredient. Therefore, if your doctor has decided that Viagra is safe for you, it means that you can also use Generic Viagra. How does Generic Viagra work? It increases your ability to have and sustain an erection by inhibiting the enzymes that degrade the cyclic guanosine monophosphate, a substance that facilitates the influx of blood into the penis, by relaxing its spongy tissue. In other words, Viagra dilates blood vessels in the penis, and allows the necessary inflow of blood that an erection requires. Viagra can cause erections only when a man is sexually excited. This is the reason why this drug is not for regular use. It should be taken about one hour before sexual activity, and once the sexual intercourse is over the erection goes away. The efficacy of Generic Viagra has been evaluated based on self-assessment questionnaires, and this evaluation has shown that this drug is responsible for the sexual function improvement of almost ninety percent of those who have used it to treat their erectile dysfunctions. The evaluation included firmness, frequency, and ability to maintain an erection; level and frequency of desire; frequency of orgasm; sexual intercourse satisfaction; and relationship satisfaction. When it comes to the side effects that Generic Viagra can have, it is difficult to anticipate them. Your doctor should be informed shortly after the development of a side effect has occurred, or it has changed its intensity. Some of the side effects of Generic Viagra that are more likely to be experienced by those who use it as treatment include headache, abnormal vision, diarrhea, indigestion, urinary tract infection, and nasal congestion. There are other possible side effects, but these have been experienced at a considerably lower frequency. Remember that it is hard to predict how your body will react to this drug. Chances are that you’ll be just fine, if you don’t have a preexisting condition, such as a heart problem. However, you should inform your doctor about any modification that may occur, and he/she will tell you whether or not you should keep taking Generic Viagra. It is the doctor once again that will give you the most detailed information about the food and drugs Generic Viagra interacts with. It is a well-known fact that erectile dysfunction drugs should not be used simultaneously unless prescribed by a doctor. However, Generic Viagra may interact with other drugs as well, which is why you have to consult with your doctor before taking this medicine. He or she will also inform you about the special warnings that come with this medication, and what conditions do not allow the use of Generic Viagra.viagra levitra cialis pharmacist prescription drug The most widely used remedy for erectile dysfunction; research has indicated that Viagra has an effect on the condition of the human heart as well as a male's penis. The hormonal stress normally exerted on the human heart has been noted to be decreased in men who take Viagra. When conducted with mice, the testing was more noticeable, Viagra having the tendency to avert harmful and long term effects of chronic hypertension on their heart. The study, lead by the John Hopkins research team, found that there is potential benefits for the treatment of pulmonary hypertension, linked in with how Viagra dilates genital blood vessels. Viagra works by dulling the heart beat, which is increased during stress. It works to decrease the force which is needed to pump blood from the heart to the rest of the body. The research conducted by David Kass, cardiologist and senior researcher of the John Hopkins study noticed Viagra can be effective in blocking short- term consequences of hormonal stresses in the heart. Further evidence on the testing of mice (although further research is needed until this is applicable to humans), indicated that negative effects of heart failure and cardiac hypertrophy on weakened heart muscles can be reversed. Further research is need in this area on humans however. Thirty five men and women were tested and injected with Dobutamine (a synthetic derivative of dopamine that increases heart rate and contractions), which resulted in increased rate of 150%. The men and women were then separated into two groups, one of which were given sildenafil (Viagra) and the other given a placebo (fake) pill. Results showed that the first group's heart rate decreased by 50%, whilst the latter group's further increased. This has led to widespread scientific interest in the effects of sildenafil (Viagra) on the human heart condition. buying sildenafil Sildenafil Tablets 25 mg, 50 mg, 100 mg (sil-DEN-a-fil) Treating erectile dysfunction (ED). It may also be used for other conditions as determined by your doctor. Viagra is a phosphodiesterase inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection. you are taking nitrates (eg, isosorbide, nitroglycerin) in any form (eg, tablet, capsule, patch, ointment) or nitroprusside you use certain recreational drugs called "poppers" (eg, amyl nitrate, butyl nitrate) Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Viagra . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a deformed penis (eg, Peyronie disease, cavernosal fibrosis), blood problems (eg, sickle cell anemia, leukemia, multiple myeloma), or any other condition that may increase the risk of a prolonged erection (eg, priapism) if you have a history of certain eye problems (eg, retinitis pigmentosa, sudden vision loss, optic neuropathy, macular degeneration) if you have a history of liver or kidney problems, high or low blood pressure, ulcers, bleeding problems, heart problems (eg, heart failure, irregular heartbeat, aortic stenosis, angina), or blood vessel problems if you have a history of heart attack, stroke, or life-threatening irregular heartbeat, especially within the past 6 months Some MEDICINES MAY INTERACT with Viagra . Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole), cimetidine, H2 agonists (eg, famotidine), HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, erythromycin), or telithromycin because they may increase the risk of Viagra 's side effects This may not be a complete list of all interactions that may occur. Ask your health care provider if Viagra may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Use Viagra as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with Viagra . Talk to your pharmacist if you have questions about this information. Take Viagra by mouth with or without food. Viagra may not work as quickly if you take it with a high-fat meal. Viagra is usually taken about 1 hour before sexual activity. However, it may be taken anywhere from 4 hours to ? hour before sexual activity. Talk with your doctor about the best way to take Viagra . Do not take Viagra more often than once daily, or as directed by your doctor. If you miss a dose of Viagra and you still intend to engage in sexual activity, take it as soon as you remember. Continue to take it as directed by your doctor. Ask your health care provider any questions you may have about how to use Viagra . Viagra may cause dizziness, drowsiness, fainting, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Viagra with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Viagra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Patients with heart problems who take Viagra may be at increased risk for heart-related side effects, including heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms. Viagra may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Do not use other medicines or treatments for erectile dysfunction while you are taking Viagra . Viagra does not stop the spread of HIV or other sexually transmitted diseases (STDs) to others through sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection or an STD. Viagra will not prevent pregnancy. If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control. Use Viagra with caution in the ELDERLY; they may be more sensitive to its effects. Viagra is not recommended for use in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Viagra is not approved for use in women. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Viagra while you are pregnant. It is not known if Viagra is found in breast milk. If you are or will be breast-feeding while you use Viagra , check with your doctor. Discuss any possible risks to your baby. All medicines may cause side effects, but many people have no, or minor, side effects. Diarrhea; dizziness; flushing; headache; heartburn; mild, temporary vision changes (eg, blurred vision, sensitivity to light, blue/green color tint to vision); stuffy nose; upset stomach. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; painful or prolonged erection; ringing in the ears; seizure; severe or persistent dizziness; severe or persistent vision changes; sudden decrease or loss of vision in one or both eyes; sudden hearing loss. This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at . Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( ), or emergency room immediately. Symptoms may include chest pain; fainting; prolonged erection; severe dizziness. Store Viagra at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Viagra out of the reach of children and away from pets. If you have any questions about Viagra , please talk with your doctor, pharmacist, or other health care provider. Viagra is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. This information is a summary only. It does not contain all information about Viagra . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider. sildenafil citrate active ingredient According to research on mice, Viagra may play a prominent role in reversing growth abnormalities in the heart. Researchers are of the opinion that Viagra reversed the abnormal growth of heart muscles and restored normal heart function to mice with enlarged hearts. A larger-than-normal heart is quite a serious medical condition. Commonly termed as hypertrophy, it is a main feature of heart failure and can be fatal. The condition develops because of chronically uncontrolled high blood pressure. This forces the heart to pump harder to satisfy the body's requirements; to adapt to these high pressures, the muscles of the heart enlarge. Individuals with hypertrophy (enlarged hearts) have a much higher probability of developing heart disease, heart failure or sudden cardiac death. The study states that Viagra may turn out to be an effective treatment for a chronic heart condition. The next point of action will be to conduct research to see if the Viagra will have the same advantageous effect in humans that it had shown in mice. It is also has come to the conclusion that the enzyme pathway blocked by sildenafil (PDE5A), never before known to play a prominent part in the heart, is charged when the heart is exposed to pressure stress and hypertrophied. The findings of the study provide a few of the strongest proofs that blocking the heart's adaptive response to hypertrophy does not harm its function but may improve it. Researchers come to the conclusion that heart function, normally measured by pressure/volume analysis of the muscle's ability to contract and pump blood, surprisingly improved after hypertrophy had been halted and treated. While researchers were of the view that that hypertrophy was an adaptive feedback to pressure stress, the functional gains lasted despite the heart's continued exposure to high blood pressure. Improvements were evident in more than ten measures of heart function, taking into account heart relaxation, cardiac output and heart contractility (which enhanced by staggering 40 percent). Furthermore, these types of improvements were evident even when therapy was deferred and initiated two weeks after hypertrophy had already developed. The study clearly demonstrates that sildenafil can eliminate hypertrophy. Its effects can not only be halted, but also reversed. The findings provide a better understanding of the biological pathways and suggest possible therapies using sildenafil. It has the added advantage of already being termed safe and effective for other medical purposes. natural viagra supplements Nuts, crocodiles and witch trials may seem to have little to do with Viagra -- but at one time or another, they've all been employed against erectile dysfunction. For centuries, doctors struggled to pinpoint the causes of male impotence, blaming such factors as stress, diet, the wrath of deities and unattractive women. Ancient Greek physician Hippocrates attributed impotence to horseback riding; one of his contemporaries placed the blame on childhood trauma; Egyptians to evil spells. The ancients also left behind an imaginative array of remedies: snacks of almonds, pistachios, dates, currant juice and bird eggs in Persia; a mix of sesame, lentils, rice and sugar cane juice in ancient India -- or goat testicles boiled in milk or butter and boiled alligator testes rubbed on the feet. The Egyptians were more direct, smearing remedies (such as crocodile hearts and wood oil) directly on the penis. In the Islamic empire, impotence was sometimes blamed on an imbalance in the four fluids, or humors, thought to course through the body. Doctors advised men to avoid sex after meals, in the bathroom and with old or unappealing partners. In medieval Europe, impotent men believed they were under spells cast by witches, but also blamed their wives. Impotence was grounds for divorce. In the Victorian era, many thought impotence was due to a depletion of sperm. Doctors cautioned against masturbation (a "waste" of sperm) and prescribed quinine, opium, digitalis and bleeding, to no avail. In the late 1800s, French professor of medicine Charles Edouard Brown-Sequard proposed that injections of animal sperm might restore vitality. He tested the theory by injecting himself with an extract of dog and guinea pig testicles. His colleagues, who agreed the professor looked good for a man of 72, agreed to test the extracts on their patients. Soon the treatment, organotherapy, was all the rage. Starting in the late 1910s, a few doctors went a step further, deciding to transplant whole testicles. In France, Serge Voronoff transplanted monkey testicles into the nether regions of more than 1,000 old men. In Kansas, John Brinkley ran a hospital that specialized in grafting goat testicles onto patients. At a California prison, Leo Stanley gave older inmates testicles of younger, executed prisoners. Although many men claimed to feel rejuvenated by their testicular shots and transplants, few recovered their virility, and researchers continued their search. In the 1930s doctors experimented with surgical adjustment of penile muscles. In the 1940s and 1950s, they tried implants, inspired by the penile bones many animals have. In the 1960s, an effective option finally arrived. A Georgia tire serviceman began work on a vacuum pump to treat his own impotence, which was ultimately approved by the Food and Drug Administration in 1982. The pump appeared just as several researchers began to identify drug treatments for impotence, albeit few with the showmanship exhibited by British doctor Giles Brindley. At a 1983 urology meeting, Brindley injected himself with a drug, phentolamine -- then took the stage, dropped his pants and shared his erection with his colleagues. Brindley injected 33 drugs in his penis before finding one that worked, which may have rendered him slightly envious of the discoverers of Viagra. British researchers Ian Osterloh and Gill Samuels were developing a drug to improve blood flow to the heart when they realized that the drug, sildenafil citrate, was much more effective at improving blood flow to the penis -- and causing erections. In Viagra's first month on the market, doctors wrote well over 500,000 prescriptions. Considering men's history of options -- crocodile hearts, prayer, testicular shots and grafts -- perhaps the blue pill's lasting popularity should come as no surprise. free viagra sample Drug Cialis for daily use. in 2003, and in 2007 alone they had a wopping figure of $798 million although this year it is expected to top over $1 billion in sales. They will report the official sale figures year-end January 29th. The once-a-day version will be marketed to men who anticipate having sex two or more times a week, without confining it to a limited time frame. When Cialis is taken daily, men can attempt sexual activity at any time. The low-dose daily version of the drug already is available in parts of Europe, Lilly said. Neither Viagra nor Levitra, a pair of competitors, is sold in once-daily doses. Althought Cialis maybe aggressively approaching the market with a new idea, was founded five years before Cialis company, and remains to be the most branded and popular erectile dysfunction drug in the World! buy xenical viagra propecia com This is a summary of the most important information about Viagra. For details, talk to your healthcare professional. FDA ALERT [7/2005]: A small number of men have lost eyesight in one eye some time after taking Viagra, Cialis, or Levitra. This type of vision loss is called non-arteritic anterior ischemic optic neuropathy (NAION). NAION causes a sudden loss of eyesight because blood flow is blocked to the optic nerve. We do not know at this time if Viagra, Cialis, or Levitra causes NAION. NAION also happens in men who do not take these medicines. People who have a higher chance for NAION include those who: FDA has approved new labels for Viagra, Cialis, and Levitra to include information on possible eyesight loss (NAION). Stop using Viagra, Cialis, or Levitra if you have a loss in your eyesight. Get medical help right away. This information reflects FDA's current analysis of data available to FDA concerning this drug. FDA intends to update this sheet when additional information or analyses become available. What is Viagra? Viagra is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men. ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. Viagra may help a man with ED get and keep an erection when he is sexually excited. Viagra must be used only under a doctor's care. protect a man or his partner from sexually transmitted diseases, including HIV. Speak to your healthcare professional about ways to guard against sexually transmitted diseases. Viagra is only for men with ED. Viagra is not for women or children. Viagra must be used only under a healthcare professional's care. Who Should Not Take Viagra? What are The Risks? The following are the major possible risks and side effects of Viagra therapy. This list is not complete. Viagra can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines such as nitrates and alpha-blockers, and recreational drugs that contain nitrates called "poppers". A sudden drop in your blood pressure could cause you to become dizzy, faint, or have a heart attack or stroke. Tell all your healthcare professionals that you take Viagra. If you need emergency medical care for a heart problem, it will be important for your healthcare professionals to know when you last took Viagra. vision changes, such as seeing a blue tinge to objects or having difficulty telling the difference between the colors blue and green What Should I Tell My Healthcare Professional? have retinitis pigmentosa, a rare genetic (runs in families) eye disease have blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia Can Other Medicines or Food Affect Viagra? Viagra and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them with you to show your healthcare professional. Date created: July 8, 2005, updated October 2, 2007 |
| An oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is designated chemically as 1 - [[3 - (6,7 - dihydro - 1 - methyl - 7 - oxo - 3 - propyl - 1H - pyrazolo[4,3 - d]pyrimidin - 5 - yl) - 4 - ethoxyphenyl]sulfonyl] - 4 - methylpiperazine citrate and has the following structural formula: Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7. Viagra (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation. Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels (see ). In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo. Viagra is rapidly absorbed after oral administration, with absolute bioavailability of about 40%. Its pharmacokinetics are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil. The concomitant use of potent cytochrome P450 3A4 inhibitors (e.g., erythromycin, ketoconazole, itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of sildenafil (see ). Both sildenafil and the metabolite have terminal half lives of about 4 hours. in Healthy Male Volunteers. Viagra is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When Viagra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in T of 29%. The mean steady state volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations. Based upon measurements of sildenafil in semen of healthy volunteers 90 minutes after dosing, less than 0.001% of the administered dose may appear in the semen of patients. Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose). Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach. Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, with free plasma concentrations approximately 40% greater than those seen in healthy younger volunteers (18–45 years). In volunteers with mild (CLcr=50–80 mL/min) and moderate (CLcr=30–49 mL/min) renal impairment, the pharmacokinetics of a single oral dose of Viagra (50 mg) were not altered. In volunteers with severe (CLcr=<30 mL/min) renal impairment, sildenafil clearance was reduced, resulting in approximately doubling of AUC and C compared to age-matched volunteers with no renal impairment. In volunteers with hepatic cirrhosis (Child-Pugh A and B), sildenafil clearance was reduced, resulting in increases in AUC (84%) and C (47%) compared to age-matched volunteers with no hepatic impairment. Therefore, age >65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 25 mg should be considered in those patients (see ). In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by an objective measurement of hardness and duration of erections (RigiScan ), after Viagra administration compared with placebo. Most studies assessed the efficacy of Viagra approximately 60 minutes post dose. The erectile response, as assessed by RigiScan , generally increased with increasing sildenafil dose and plasma concentration. The time course of effect was examined in one study, showing an effect for up to 4 hours but the response was diminished compared to 2 hours. Single oral doses of sildenafil (100 mg) administered to healthy volunteers produced decreases in supine blood pressure (mean maximum decrease in systolic/diastolic blood pressure of 8.4/5.5 mmHg). The decrease in blood pressure was most notable approximately 1–2 hours after dosing, and was not different than placebo at 8 hours. Similar effects on blood pressure were noted with 25 mg, 50 mg and 100 mg of Viagra, therefore the effects are not related to dose or plasma levels within this dosage range. Larger effects were recorded among patients receiving concomitant nitrates (see ). Systolic Blood Pressure, Healthy Volunteers. Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. Studies have produced relevant data on the effects of Viagra on cardiac output. In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. A total dose of 40 mg sildenafil was administered by four intravenous infusions. The results from this pilot study are shown in Table 1; the mean resting systolic and diastolic blood pressures decreased by 7% and 10% compared to baseline in these patients. Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28%, 28%, 20% and 7% respectively. Even though this total dosage produced plasma sildenafil concentrations which were approximately 2 to 5 times higher than the mean maximum plasma concentrations following a single oral dose of 100 mg in healthy male volunteers, the hemodynamic response to exercise was preserved in these patients. In a double-blind study, 144 patients with erectile dysfunction and chronic stable angina limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or Viagra 100 mg 1 hour prior to exercise testing. The primary endpoint was time to limiting angina in the evaluable cohort. The mean times (adjusted for baseline) to onset of limiting angina were 423.6 and 403.7 seconds for sildenafil (N=70) and placebo, respectively. These results demonstrated that the effect of Viagra on the primary endpoint was statistically non-inferior to placebo. At single oral doses of 100 mg and 200 mg, transient dose-related impairment of color discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test, with peak effects near the time of peak plasma levels. This finding is consistent with the inhibition of PDE6, which is involved in phototransduction in the retina. An evaluation of visual function at doses up to twice the maximum recommended dose revealed no effects of Viagra on visual acuity, intraocular pressure, or pupillometry. In clinical studies, Viagra was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. Viagra was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover). Viagra was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years. Viagra demonstrated statistically significant improvement compared to placebo in all 21 studies. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. The effectiveness of Viagra was evaluated in most studies using several assessment instruments. The primary measure in the principal studies was a sexual function questionnaire (the International Index of Erectile Function - IIEF) administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment. Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration. The patient addressed both questions at the final visit for the last 4 weeks of the study. The possible categorical responses to these questions were (0) no attempted intercourse, (1) never or almost never, (2) a few times, (3) sometimes, (4) most times, and (5) almost always or always. Also collected as part of the IIEF was information about other aspects of sexual function, including information on erectile function, orgasm, desire, satisfaction with intercourse, and overall sexual satisfaction. Sexual function data were also recorded by patients in a daily diary. In addition, patients were asked a global efficacy question and an optional partner questionnaire was administered. The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 3, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function. Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg. The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse. The titration studies, in which most patients received 100 mg, showed similar results. Figure 3 shows that regardless of the baseline levels of function, subsequent function in patients treated with Viagra was better than that seen in patients treated with placebo. At the same time, on-treatment function was better in treated patients who were less impaired at baseline. Figure 3. Effect of Viagra and Placebo on Maintenance of Erection by Baseline Score. The frequency of patients reporting improvement of erections in response to a global question in four of the randomized, double-blind, parallel, placebo-controlled fixed dose studies (1797 patients) of 12 to 24 weeks duration is shown in Figure 4. These patients had erectile dysfunction at baseline that was characterized by median categorical scores of 2 (a few times) on principal IIEF questions. Erectile dysfunction was attributed to organic (58%; generally not characterized, but including diabetes and excluding spinal cord injury), psychogenic (17%), or mixed (24%) etiologies. Sixty-three percent, 74%, and 82% of the patients on 25 mg, 50 mg and 100 mg of Viagra, respectively, reported an improvement in their erections, compared to 24% on placebo. In the titration studies (n=644) (with most patients eventually receiving 100 mg), results were similar. Figure 4. Percentage of Patients Reporting an Improvement in Erections. The patients in studies had varying degrees of ED. One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period. In many of the studies, of both fixed dose and titration designs, daily diaries were kept by patients. In these studies, involving about 1600 patients, analyses of patient diaries showed no effect of Viagra on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged 1.3 on 50–100 mg of Viagra vs 0.4 on placebo; similarly, group mean success rates (total successes divided by total attempts) were about 66% on Viagra vs about 20% on placebo. During 3 to 6 months of double-blind treatment or longer-term (1 year), open-label studies, few patients withdrew from active treatment for any reason, including lack of effectiveness. At the end of the long-term study, 88% of patients reported that Viagra improved their erections. Men with untreated ED had relatively low baseline scores for all aspects of sexual function measured (again using a 5-point scale) in the IIEF. Viagra improved these aspects of sexual function: frequency, firmness and maintenance of erections; frequency of orgasm; frequency and level of desire; frequency, satisfaction and enjoyment of intercourse; and overall relationship satisfaction. One randomized, double-blind, flexible-dose, placebo-controlled study included only patients with erectile dysfunction attributed to complications of diabetes mellitus (n=268). As in the other titration studies, patients were started on 50 mg and allowed to adjust the dose up to 100 mg or down to 25 mg of Viagra; all patients, however, were receiving 50 mg or 100 mg at the end of the study. There were highly statistically significant improvements on the two principal IIEF questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) on Viagra compared to placebo. On a global improvement question, 57% of Viagra patients reported improved erections versus 10% on placebo. Diary data indicated that on Viagra, 48% of intercourse attempts were successful versus 12% on placebo. One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erect |
